Examples of our virotherapy process development activities include:
- Virus rescue on cells by multiple-plasmid transfection
- Virus cloning by plaque or limited dilution methods
- Adaptation of adherent cells to suspension
- Weaning of cultures to serum-free conditions
- RCB and RVSS generation
- Optimization of Multiplicity of Infection (MOI), Point of Infection (POI) and Point of Harvest (POH)
- System/vessel feasibility studies for your virus product
- Evaluation/optimization of medium and supplements
- Optimization of virus recovery from bulk harvest
- Fermentation development focusing on disposable systems
- Purification development comprising filtration and chromatographic techniques
- Generation of purified virus reference materials by batch ultra-centrifugation
- Virus genomic stability studies
- Assay integration/development particularly covering live virus products
Our specialists will support you through each stage of process development.