Process development

Our process development services are based on a systematic, stepwise methodology focused on the identification of key process parameters. Our approach is resource efficient, reducing development time and costs, without compromising quality.

Our aim is to create functional, scalable, and most importantly transferable processes based on established GMP manufacturing principles. Having GMP in mind from the beginning, we develop based on single-use processing platforms for both UPS and DPS.

Our expertise in working with high demand organisms and familiarity with viruses such as adenovirus, Vesicular stomatitis virus (VSV), herpesvirus, Adeno Associated Virus (AAV), Modified vaccinia virus ankara (MVA), measles and others, makes us ideal partners for complex projects.

Working with Vibalogics will help you meet the expectations of your stakeholders, whether you want to enter the clinic quickly, or spend more time to develop a process with commercial requirements in mind.

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Examples of our virotherapy process development activities include:

Virus rescue on cells by multiple-plasmid transfection
Virus cloning by plaque or limited dilution methods
Adaptation of adherent cells to suspension
Weaning of cultures to serum-free conditions
RCB and RVSS generation
Optimization of Multiplicity of Infection (MOI), Point of Infection (POI) and Point of Harvest (POH)
System/vessel feasibility studies for your virus product
Evaluation/optimization of medium and supplements
Optimization of virus recovery from bulk harvest
Fermentation development focusing on disposable systems
Purification development comprising filtration and chromatographic techniques
Generation of purified virus reference materials by batch ultra-centrifugation
Virus genomic stability studies
Assay integration/development particularly covering live virus products

Our specialists will support you through each stage of process development.

Our Statement on Covid 19